Cloned (Comment) | Organism |
---|---|
the mutant enzyme T259I is expressed in Escherichia coli XL1 Blue cells and in Yersinia pestis strain KIM D34 | Yersinia pestis |
Protein Variants | Comment | Organism |
---|---|---|
T259I | the substitution impairs fibrinolytic activity and plasminogen activation | Yersinia pestis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | outer membrane | Yersinia pestis | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha2-antiplasmin + H2O | Yersinia pestis | Pla inactivates alpha2-antiplasmin | ? | - |
? | |
plasminogen + H2O | Yersinia pestis | - |
plasmin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Yersinia pestis | - |
lineages Microtus and Angola | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha2-antiplasmin + H2O | Pla inactivates alpha2-antiplasmin | Yersinia pestis | ? | - |
? | |
plasminogen + H2O | - |
Yersinia pestis | plasmin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta-Pla | - |
Yersinia pestis |
Pla | - |
Yersinia pestis |
General Information | Comment | Organism |
---|---|---|
physiological function | the outer membrane plasminogen activator Pla of Yersinia pestis is a central virulence factor in plague | Yersinia pestis |